Focused transcranial ultrasound for treatment of neurodegenerative dementia.

Publication Title

Alzheimers Dement (N Y)

Authors

Natalie Eleanor Nicodemus
Sergio Becerra
Taylor P Kuhn
Hannah R Packham
John Duncan
Kennedy Mahdavi
Jessica Iovine
Santosh Kesari, Department of Translational Neurosciences and Neurotherapeutics, Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Scott Pereles
Mike Whitney
Michael Mamoun
Daniel Franc
Alexander Bystritsky
Sheldon Jordan

Document Type

Article

Publication Date

1-1-2019

Abstract

Introduction: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).

Methods: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm

Results: Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported.

Discussion: The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.

Area of Special Interest

Neurosciences (Brain & Spine)

Specialty/Research Institute

Neurosciences