Title

Genomic, Proteomic, and Immunologic Associations with a Durable Complete Remission of Measurable Metastatic Melanoma Induced by a Patient-Specific Dendritic Cell Vaccine.

Authors

Robert O Dillman, Hoag Cancer Institute , Newport Beach , CA 92663
Gabriel I Nistor
Aleksandra J Poole

Document Type

Article

Publication Date

10-18-2019

Publication Title

Hum Vaccin Immunother

Abstract

This report describes efforts to understand the immune mechanism of action that led to a complete response in a patient with progressive, refractory, metastatic melanoma after treatment with a therapeutic vaccine consisting of autologous dendritic cells (DC) loaded with autologous tumor antigens (ATA) derived from cells that were self-renewing in cell culture. Her histocompatibility type proved to be HLA B27 with extensive mutations in the HLA-A locus. Exomic analysis of proliferating tumor cells revealed more than 2,800 non-synonymous mutations compared to her leukocytes. Histology of resected tumor lesions showed no evidence of an existing or suppressed immune response. In

Clinical Institute

Cancer

Department

Oncology

Recommended Citation

Dillman, Robert O; Nistor, Gabriel I; and Poole, Aleksandra J, "Genomic, Proteomic, and Immunologic Associations with a Durable Complete Remission of Measurable Metastatic Melanoma Induced by a Patient-Specific Dendritic Cell Vaccine." (2019). Articles, Abstracts, and Reports. 2217.
https://digitalcommons.providence.org/publications/2217