Publication Title
Mol Syst Biol
Document Type
Article
Publication Date
3-26-2018
Keywords
Huntington's disease; SMAD3; transcription factor; transcriptional regulatory networks; Animals; Corpus Striatum/metabolism; Disease Models, Animal; Gene Expression Profiling/methods; Gene Expression Regulation; Gene Regulatory Networks; Humans; Huntington Disease/genetics; Huntington Disease/metabolism; Mice; Protein Interaction Maps; Proteomics; Smad3 Protein/genetics; Smad3 Protein/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism
Abstract
Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD We reconstructed a genome-scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by integrating a model of genomic binding sites with transcriptome profiling of striatal tissue from HD mouse models. We identified 48 differentially expressed TF-target gene modules associated with age- and CAG repeat length-dependent gene expression changes in
Clinical Institute
Neurosciences (Brain & Spine)
Specialty/Research Institute
Institute for Systems Biology
Specialty/Research Institute
Neurosciences
