Unresectable hepatoblastoma: current perspectives.

Publication Title

Hepat Med

Authors

Angela D Trobaugh-Lotrario, Department of Pediatric Hematology and Oncology, Providence Sacred Heart Children's Hospital, Spokane, WA.
Rebecka L Meyers
Allison F O'Neill
James H Feusner

Document Type

Article

Publication Date

1-1-2017

Keywords

hepatoblastoma; pediatric; unresectable

Abstract

Although rare, hepatoblastoma is the most common pediatric liver tumor. Complete resection is a critical component for cure; however, most patients will have tumors that are not resected at diagnosis. For these patients, administration of neoadjuvant chemotherapy renders tumors resectable in most patients. For patients whose tumors remain unresectable after chemotherapy, liver transplantation is indicated (in the absence of active unresectable metastatic disease). In patients whose tumors remain unresectable after conventional chemotherapy, interventional techniques may serve as a promising option to reduce tumor size, decrease systemic toxicity, decrease need for liver transplantation, and increase feasibility of tumor resection.

Area of Special Interest

Cancer

Area of Special Interest

Women & Children

Specialty/Research Institute

Oncology

Specialty/Research Institute

Pediatrics

Specialty/Research Institute

Surgery