Publication Title
Nutrition and cancer
Document Type
Article
Publication Date
4-1-2017
Keywords
Animals; Antioxidants; Carcinogens; Cells, Cultured; Curcuma; Curcumin; Epithelial Cells; Ferric Compounds; Iron; Iron Overload; Liver; Liver Neoplasms; Oxidative Stress; Plant Extracts; Quaternary Ammonium Compounds; Rats
Abstract
Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
