Publication Title

Nature methods

Document Type

Article

Publication Date

3-1-2017

Keywords

Chromatography, Liquid; Databases, Protein; Genome, Human; Humans; Proteome; Proteomics; Tandem Mass Spectrometry

Abstract

We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.

Specialty/Research Institute

Institute for Systems Biology

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