Publication Title
Nature methods
Document Type
Article
Publication Date
3-1-2017
Keywords
Chromatography, Liquid; Databases, Protein; Genome, Human; Humans; Proteome; Proteomics; Tandem Mass Spectrometry
Abstract
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.
Specialty
Institute for Systems Biology
