Publication Title
Nature methods
Document Type
Article
Publication Date
3-1-2017
Keywords
Chromatography, Liquid; Databases, Protein; Genome, Human; Humans; Proteome; Proteomics; Tandem Mass Spectrometry
Abstract
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.
Specialty
Institute for Systems Biology
Recommended Citation
Zolg, Daniel P; Wilhelm, Mathias; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Delanghe, Bernard; Bailey, Derek J; Gessulat, Siegfried; Ehrlich, Hans-Christian; Weininger, Maximilian; Yu, Peng; Schlegl, Judith; Kramer, Karl; Schmidt, Tobias; Kusebauch, Ulrike; Deutsch, Eric W; Aebersold, Ruedi; Moritz, Robert L; Wenschuh, Holger; Moehring, Thomas; Aiche, Stephan; Huhmer, Andreas; Reimer, Ulf; and Kuster, Bernhard, "Building ProteomeTools based on a complete synthetic human proteome." (2017). Articles, Abstracts, and Reports. 2389.
https://digitalcommons.providence.org/publications/2389
