Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.
Publication Title
Cancer research
Document Type
Article
Publication Date
12-15-2019
Abstract
Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or
Clinical Institute
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Institute for Systems Biology
COinS
