Title

Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.

Authors

Guo Chen
Dongkyoo Park
Andrew T Magis, Institute for Systems Biology, Seattle, Washington.
Madhusmita Behera
Suresh S Ramalingam
Taofeek K Owonikoko
Gabriel L Sica
Keqiang Ye
Chao Zhang
Zhengjia Chen
Walter J Curran
Xingming Deng

Document Type

Article

Publication Date

12-15-2019

Publication Title

Cancer research

Abstract

Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or

Clinical Institute

Cancer

Department

Oncology

Department

Institute for Systems Biology

Recommended Citation

Chen, Guo; Park, Dongkyoo; Magis, Andrew T; Behera, Madhusmita; Ramalingam, Suresh S; Owonikoko, Taofeek K; Sica, Gabriel L; Ye, Keqiang; Zhang, Chao; Chen, Zhengjia; Curran, Walter J; and Deng, Xingming, "Mcl-1 Interacts with Akt to Promote Lung Cancer Progression." (2019). Articles, Abstracts, and Reports. 2532.
https://digitalcommons.providence.org/publications/2532