Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury.
Publication Title
The British journal of radiology
Document Type
Article
Publication Date
9-1-2019
Keywords
Brain; Brain Injuries, Traumatic; Chronic Traumatic Encephalopathy; Diagnostic Imaging; Humans; Neuroimaging
Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is of epidemic proportions in contact sports athletes and is linked to subconcussive and concussive repetitive head impacts (RHI). Although postmortem analysis is currently the only confirmatory method to diagnose CTE, there has been progress in early detection techniques of fluid biomarkers as well as in advanced neuroimaging techniques. Specifically, promising new methods of diffusion MRI and radionucleotide PET scans could aid in the early detection of CTE.The authors examine early detection methods focusing on various neuroimaging techniques. Advances in structural and diffusion MRI have demonstrated the ability to measure volumetric and white matter abnormalities associated with CTE. Recent studies using radionucleotides such as flortaucipir and
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
