Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury.

Document Type


Publication Date


Publication Title

The British journal of radiology


Brain; Brain Injuries, Traumatic; Chronic Traumatic Encephalopathy; Diagnostic Imaging; Humans; Neuroimaging


Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is of epidemic proportions in contact sports athletes and is linked to subconcussive and concussive repetitive head impacts (RHI). Although postmortem analysis is currently the only confirmatory method to diagnose CTE, there has been progress in early detection techniques of fluid biomarkers as well as in advanced neuroimaging techniques. Specifically, promising new methods of diffusion MRI and radionucleotide PET scans could aid in the early detection of CTE.The authors examine early detection methods focusing on various neuroimaging techniques. Advances in structural and diffusion MRI have demonstrated the ability to measure volumetric and white matter abnormalities associated with CTE. Recent studies using radionucleotides such as flortaucipir and

Clinical Institute

Neurosciences (Brain & Spine)