Publication Title
Ann Transl Med
Document Type
Article
Publication Date
12-1-2019
Keywords
Ganglioside D3 synthase (GD3s); biomarker; methylation; prognosis; triple-negative breast cancer (TNBC)
Abstract
Background: Breast cancer remains a major health problem in the world. Triple-negative breast cancer (TNBC) is an aggressive subtype with very poor prognosis. Up to now, the mechanism behind TNBC's activity is still unclear and no candidate drug target has been identified. Thus, it is of critical importance to elucidate the pathways in TNBC and identify the relevant biomarkers. Recent studies showed that ganglioside D3 synthase (GD3s) played a very important role in development of cancers. However, the physiological functions and associated pathways of GD3s in TNBC are still unclear.
Methods:
Results:
Conclusions: In summary, these results suggest that GD3s may be a potential biomarker and drug target in treatment of TNBC.
Area of Special Interest
Cancer
Area of Special Interest
Women & Children
Specialty/Research Institute
Oncology
