Epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer.

Authors

Wan Li
Xiangjin Zheng
Liwen Ren
Weiqi Fu
Jinyi Liu
Jun Xv
Shiwei Liu
Jinhua Wang, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA, USA
Guanhua Du

Document Type

Article

Publication Date

12-1-2019

Publication Title

Ann Transl Med

Keywords

Ganglioside D3 synthase (GD3s); biomarker; methylation; prognosis; triple-negative breast cancer (TNBC)

Abstract

Background: Breast cancer remains a major health problem in the world. Triple-negative breast cancer (TNBC) is an aggressive subtype with very poor prognosis. Up to now, the mechanism behind TNBC's activity is still unclear and no candidate drug target has been identified. Thus, it is of critical importance to elucidate the pathways in TNBC and identify the relevant biomarkers. Recent studies showed that ganglioside D3 synthase (GD3s) played a very important role in development of cancers. However, the physiological functions and associated pathways of GD3s in TNBC are still unclear.

Methods:

Results:

Conclusions: In summary, these results suggest that GD3s may be a potential biomarker and drug target in treatment of TNBC.

Clinical Institute

Cancer

Clinical Institute

Women & Children

Department

Oncology

Recommended Citation

Li, Wan; Zheng, Xiangjin; Ren, Liwen; Fu, Weiqi; Liu, Jinyi; Xv, Jun; Liu, Shiwei; Wang, Jinhua; and Du, Guanhua, "Epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer." (2019). Articles, Abstracts, and Reports. 2864.
https://digitalcommons.providence.org/publications/2864