Title

The building blocks of successful translation of proteomics to the clinic.

Authors

Paul Kearney
J Jay Boniface
Nathan D Price, Institute for Systems Biology, Seattle, WA, United StatesFollow
Leroy Hood, Institute for Systems Biology, Seattle, WA, United StatesFollow

Document Type

Article

Publication Date

2-6-2018

Publication Title

Current opinion in biotechnology

Abstract

Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.

Department

Institute for Systems Biology

Recommended Citation

Kearney, Paul; Boniface, J Jay; Price, Nathan D; and Hood, Leroy, "The building blocks of successful translation of proteomics to the clinic." (2018). Articles, Abstracts, and Reports. 31.
https://digitalcommons.providence.org/publications/31