Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease.
Publication Title
Clinics in liver disease
Document Type
Article
Publication Date
8-1-2020
Abstract
Alpha1-antitrypsin deficiency (A1ATD) is an inherited cause of chronic liver disease. It is inherited in an autosomal codominant pattern with each inherited allele expressed in the formation of the final protein, which is primarily produced in hepatocytes. The disease usually occurs in pediatric and elderly populations. The disease occurs with the accumulation of abnormal protein polymers within hepatocytes that can induce liver injury and fibrosis. It is a commonly under-recognized and underdiagnosed condition. Patients diagnosed with the disease should be regularly monitored for the development of liver disease. Liver transplant is of proven benefit in A1ATD liver disease.
Area of Special Interest
Digestive Health
Specialty/Research Institute
Hepatology
Specialty/Research Institute
Gastroenterology
