Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease.

Publication Title

Clinics in liver disease

Document Type

Article

Publication Date

8-1-2020

Abstract

Alpha1-antitrypsin deficiency (A1ATD) is an inherited cause of chronic liver disease. It is inherited in an autosomal codominant pattern with each inherited allele expressed in the formation of the final protein, which is primarily produced in hepatocytes. The disease usually occurs in pediatric and elderly populations. The disease occurs with the accumulation of abnormal protein polymers within hepatocytes that can induce liver injury and fibrosis. It is a commonly under-recognized and underdiagnosed condition. Patients diagnosed with the disease should be regularly monitored for the development of liver disease. Liver transplant is of proven benefit in A1ATD liver disease.

Clinical Institute

Digestive Health

Specialty

Hepatology

Specialty

Gastroenterology

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