Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Document Type

Article

Publication Date

9-1-2020

Keywords

bioactive lipid; carcinogenesis; cell death; inflammation resolution; soluble epoxide hydrolase

Abstract

Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced apoptosis may trigger escape from dormancy of microtumors by interfering with inflammation resolution and triggering an endoplasmic reticulum (ER) stress response. While eicosanoid and cytokine storms are well-characterized in infection and inflammation, they are poorly characterized in cancer. Here, we demonstrate that carcinogens, such as aflatoxin B

Area of Special Interest

Cancer

Specialty/Research Institute

Institute for Systems Biology

Specialty/Research Institute

Oncology

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