Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
Publication Title
Proceedings of the National Academy of Sciences of the United States of America
Document Type
Article
Publication Date
9-1-2020
Keywords
bioactive lipid; carcinogenesis; cell death; inflammation resolution; soluble epoxide hydrolase
Abstract
Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced apoptosis may trigger escape from dormancy of microtumors by interfering with inflammation resolution and triggering an endoplasmic reticulum (ER) stress response. While eicosanoid and cytokine storms are well-characterized in infection and inflammation, they are poorly characterized in cancer. Here, we demonstrate that carcinogens, such as aflatoxin B
Clinical Institute
Cancer
Specialty/Research Institute
Institute for Systems Biology
Specialty/Research Institute
Oncology
COinS
