Maternal-fetal genetic interactions, imprinting, and risk of placental abruption.
Publication Title
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Document Type
Article
Publication Date
9-24-2020
Keywords
Genetic variation; fetal; genetic interactions; imprinting; maternal
Abstract
BACKGROUND: Maternal genetic variations, including variations in mitochondrial biogenesis (MB) and oxidative phosphorylation (OP), are associated with placental abruption (PA). However, the role of maternal-fetal genetic interactions (MFGI) and parent-of-origin (imprinting) effects in PA remain unknown.
OBJECTIVE: To investigate MFGI in MB-OP, and imprinting effects in relation to risk of PA.
METHODS: Among Peruvian mother-infant pairs (503 PA cases and 1052 controls), independent single nucleotide polymorphisms (SNPs), with linkage-disequilibrium coefficient
RESULTS: Abruption cases were more likely to experience preeclampsia, have shorter gestational age, and deliver infants with lower birthweight compared with controls. Models with MFGI effects provided improved fit than models with only maternal and fetal genotype main effects for SNP rs12530904 (
CONCLUSIONS: We identified novel PA-related maternal-fetal MB gene interactions and imprinting effects that highlight the role of the fetus in PA risk development. Findings can inform mechanistic investigations to understand the pathogenesis of PA.
Clinical Institute
Women & Children
Specialty/Research Institute
Perinatology/Neonatology
Specialty/Research Institute
Epidemiology
