Characterization of Patients With Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in the US-Based Corrona Registry.
Publication Title
Arthritis Care Res (Hoboken)
Document Type
Article
Publication Date
2-6-2018
Keywords
Ankylosing spondylitis; Non-radiographic axial spondyloarthritis; Real-world data; Registry; Spondyloarthritis
Abstract
OBJECTIVE: To describe the characteristics of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) in the United States.
METHODS: Demographics, clinical characteristics, patient-reported outcomes, and treatment characteristics of patients with AS and nr-axSpA were assessed at the time of enrollment in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry. AS was defined as patients who fulfilled the 1984 modified New York criteria for AS; nr-axSpA was defined as all other patients with axSpA who did not fulfill the radiologic criterion.
RESULTS: Of the 407 patients with a diagnosis of axSpA included in this study, 310 patients (76.2%) had AS, and 97 patients (23.8%) had nr-axSpA. Although patients with nr-axSpA were younger and showed a trend for shorter symptom duration, the nr-axSpA and AS groups shared a similar disease burden, as reflected by comparisons of disease activity and function, quality of life, pain, fatigue, absenteeism, and work productivity loss (all P > 0.05). The proportions of patients receiving prior (74.2% vs 64.8%) and current biologic disease-modifying antirheumatic drugs (63.9% vs 61.3%) were also similar between patients with nr-axSpA and AS, respectively (P > 0.05).
CONCLUSION: This was the first nationwide study to characterize patients with AS and nr-axSpA in the United States. Consistent with studies published outside the United States, this study showed that patients with nr-axSpA and AS shared a comparable degree of disease burden, and had similar treatment patterns in clinical practice. This article is protected by copyright. All rights reserved.
Clinical Institute
Orthopedics & Sports Medicine
Specialty/Research Institute
Rheumatology
