Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells.
Publication Title
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Document Type
Article
Publication Date
9-30-2017
Keywords
Aminophenols; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Humans; Reactive Oxygen Species; Anticancer; Chemotherapeutic agent; Cytotoxicity; Phenols
Abstract
In this work, we report the anticancer properties of a series of 11 chemically synthesized alkylaminophenols against human osteosarcoma U2OS tumor cell line. Several assays including cytotoxicity, inhibitor kinetic study, cell migration, Annexin-V/PI double staining, reactive oxygen species (ROS) and caspase 3/7 assays were conducted on this cell line. Cytotoxic 2-((3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol was determined to have an IC
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Institute for Systems Biology
