The viral hypothesis: how herpesviruses may contribute to Alzheimer's disease.
Publication Title
Molecular psychiatry
Document Type
Article
Publication Date
5-10-2021
Abstract
The hypothesis that infectious agents, particularly herpesviruses, contribute to Alzheimer's disease (AD) pathogenesis has been investigated for decades but has long engendered controversy. In the past 3 years, several studies in mouse models, human tissue models, and population cohorts have reignited interest in this hypothesis. Collectively, these studies suggest that many of the hallmarks of AD, like amyloid beta production and neuroinflammation, can arise as a protective response to acute infection that becomes maladaptive in the case of chronic infection. We place this work in its historical context and explore its etiological implications.
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Institute for Systems Biology
Specialty/Research Institute
Neurosciences
