Systems modeling of metabolic dysregulation in neurodegenerative diseases.
Publication Title
Current opinion in pharmacology
Document Type
Article
Publication Date
8-2-2021
Keywords
genomics; washington; seattle
Abstract
Neurodegenerative diseases (NDDs) encompass a wide range of conditions that arise owing to progressive degeneration and the ultimate loss of nerve cells in the brain and peripheral nervous system. NDDs such as Alzheimer's, Parkinson's, and Huntington's diseases negatively impact both length and quality of life, due to lack of effective disease-modifying treatments. Herein, we review the use of genome-scale metabolic models, network-based approaches, and integration with multiomics data to identify key biological processes that characterize NDDs. We describe powerful systems biology approaches for modeling NDD pathophysiology by leveraging in silico models that are informed by patient-derived multiomics data. These approaches can enable mechanistic insights into NDD-specific metabolic dysregulations that can be leveraged to identify potential metabolic markers of disease and predisease states.
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Institute for Systems Biology
Specialty/Research Institute
Neurosciences
