Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19.

Publication Title

Sci Transl Med

Authors

Felice D'Agnillo
Kathie-Anne Walters, Institute for Systems Biology, Seattle, WA USAFollow
Yongli Xiao
Zong-Mei Sheng
Kelsey Scherler, Institute for Systems Biology, Seattle, WA 98109, USAFollow
Jaekeun Park
Sebastian Gygli
Luz Angela Rosas
Kaitlyn Sadtler
Heather Kalish
Charles A Blatti
Ruoqing Zhu
Lisa Gatzke
Colleen Bushell
Matthew J Memoli
Steven O'Day, John Wayne Cancer Institute, Santa Monica, CA, USA.Follow
Trevan Fischer, John Wayne Cancer Institute, Santa Monica, California, USAFollow
Terese C Hammond, John Wayne Cancer Institute at Providence Saint John's Health CenterFollow
Raymond C Lee
J Christian Cash
Matthew E Powers
Grant E O'Keefe
Kelly J Butnor
Amy V Rapkiewicz
William D Travis
Scott P Layne, Saint John's Cancer Institute, Santa Monica, CA, USAFollow
John C Kash
Jeffery K Taubenberger

Document Type

Article

Publication Date

11-17-2021

Keywords

california; santa monica; sjci; covid-19; COVID-19; Cellular Senescence; Fibrinolysis; Humans; Lung; SARS-CoV-2

Abstract

[Figure: see text].

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Pulmonary Medicine

Specialty/Research Institute

Infectious Diseases