Prognostic Utility of CpG Island Hypermethylated Phenotype in Early-Stage Invasive Primary Melanomas.

Publication Title

The Journal of investigative dermatology

Authors

Matias A Bustos, Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa MonicaFollow
Dave Hoon, Department of Translational Molecular Medicine, Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, California, USAFollow

Document Type

Article

Publication Date

1-11-2022

Keywords

california; santa monica; sjci

Abstract

In their article in the Journal of Investigative Dermatology, Conway et al. (2021) show the significance of the CpG island methylator phenotype (CIMP) subclass in early-stage invasive primary melanomas, particularly in the lentigo maligna melanoma histological subtype. CIMP melanomas had reduced melanoma-specific survival compared with intermediate and low methylation subtypes. This study emphasizes the importance of epigenomic changes in early-stage primary tumors that are associated with poor prognosis.

Clinical Institute

Cancer

Specialty/Research Institute

Dermatology

Specialty/Research Institute

Oncology