Impact of clinical outcomes and imaging measures on health-related quality of life in secondary progressive MS.
Publication Title
Multiple sclerosis (Houndmills, Basingstoke, England)
Document Type
Article
Publication Date
12-30-2021
Keywords
washington; swedish; swedish neuro; seattle; MRI; Secondary progressive MS; disability; health-related quality of life; outcome measures
Abstract
BACKGROUND: Health-related quality of life (HRQOL) outcomes are often included as secondary outcomes in clinical trials in secondary progressive MS (SPMS), but little is known about the longitudinal association of HRQOL and clinical and imaging outcome measures in SPMS.
OBJECTIVE: To assess the association of change in clinical and imaging outcomes with HRQOL in people with SPMS.
METHODS: We used data from ASCEND, a large randomized controlled trial (
RESULTS: HRQOL measures were most associated with EDSS and T25FW, less so with NHPT and SDMT, and not associated with lesional and volumetric imaging outcomes.
DISCUSSION: Worsening of the EDSS and T25FW was associated with two commonly used HRQOL measures. These outcomes therefore appear to be more patient relevant than either the NHPT or SDMT in the context of a 2-year clinical trial.
Clinical Institute
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
