Autoimmune Hemolytic Anemia in Children: Laboratory Investigation, Disease Associations, and Treatment Strategies.
Publication Title
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology
Document Type
Article
Publication Date
4-1-2022
Keywords
oregon; portland; Anemia, Hemolytic, Autoimmune; Autoantibodies; Autoimmune Diseases; Child; Hemoglobinuria, Paroxysmal; Humans; Seasons
Abstract
Autoimmune hemolytic anemia is a relatively uncommon pediatric clinical condition. As such, the evaluation and management of these cases can be challenging for even the most seasoned pediatrician. In this review, the 3 major forms of autoimmune hemolytic anemia in children will be discussed: warm autoimmune hemolytic anemia, cold agglutinin disease, and paroxysmal cold hemoglobinuria. After a general description of the laboratory approach to these entities, the pathophysiology of these disease processes, including important disease associations, will be described, and treatment strategies will be discussed. This will provide the reader with a rational approach to identifying and managing pediatric patients with these uncommon autoimmune conditions.
Area of Special Interest
Women & Children
Area of Special Interest
Cancer
Specialty/Research Institute
Pathology & Laboratory Medicine
Specialty/Research Institute
Pediatrics
Specialty/Research Institute
Hematology
