Plasmodium Parasites Viewed through Proteomics.
Publication Title
Trends in parasitology
Document Type
Article
Publication Date
8-23-2018
Keywords
Plasmodium; malaria parasites; mass spectrometry; post-translational modifications; proteomics; quantitative proteomics
Abstract
Early sequencing efforts that produced the genomes of several species of malaria parasites (Plasmodium genus) propelled transcriptomic and proteomic efforts. In this review, we focus upon some of the exciting proteomic advances from studies of Plasmodium parasites over approximately the past decade. With improvements to both instrumentation and data-processing capabilities, long-standing questions about the forms and functions of these important pathogens are rapidly being answered. In particular, global and subcellular proteomics, quantitative proteomics, and the detection of post-translational modifications have all revealed important features of the parasite's regulatory mechanisms. Finally, we provide our perspectives on future applications of proteomics to Plasmodium research, as well as suggestions for further improvement through standardization of data deposition, analysis, and accessibility.
Specialty/Research Institute
Institute for Systems Biology
