AACR Project GENIE: 100,000 cases and beyond.
Publication Title
Cancer Discov
Document Type
Article
Publication Date
7-12-2022
Keywords
oregon; portland
Abstract
The American Association for Cancer Research (AACR) Project GENIE is an international pan-cancer registry with the goal to inform cancer research and clinical care worldwide. Founded in late 2015, the milestone GENIE 9.1-public release contains data from >110,000 tumors from >100,000 people treated at 19 cancer centers from USA, Canada, the United Kingdom, France, Netherlands, and Spain. Here, we demonstrate use of these real-world data, harmonized through a centralized data resource to accurately predict enrollment on genome-guided trials, discover driver alterations in rare tumors, and identify cancer types without actionable mutations that could benefit from comprehensive genomic analysis. The extensible data infrastructure and governance framework support additional deep patient phenotyping through biopharma collaborations, and expansion to include new data types such as cell-free DNA sequencing. AACR Project GENIE continues to serve a global precision medicine knowledgebase of increasing impact to inform clinical decision making and bring together cancer researchers internationally.
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
