PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T
Publication Title
Nat Metab
Document Type
Article
Publication Date
5-1-2022
Keywords
Aging; Animals; Homeostasis; Mice; Oxidoreductases; Parkinson Disease; Protein Deglycase DJ-1; Pyruvates; T-Lymphocytes, Regulatory
Abstract
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Institute for Systems Biology
Specialty/Research Institute
Neurosciences
COinS
