Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.
Publication Title
Cancers (Basel)
Document Type
Article
Publication Date
9-6-2022
Keywords
oregon; portland; ppmc; chiles; Asian; Immunoscore; MSI; T cell; classification; colon cancer; immune response; prognostic markers; risk stratification; tumor microenvironment
Abstract
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC.
METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS).
RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19);
CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
Clinical Institute
Digestive Health
Clinical Institute
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Gastroenterology
Specialty/Research Institute
Earle A. Chiles Research Institute
