TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer

Publication Title

Journal of clinical pathology

Authors

Laura C Gomez
Mayra L Sottile
Martin E Guerrero-Gimenez
Felipe C M Zoppino
Analia L Redondo
Francisco E Gago
Javier I Orozco, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, USAFollow
Olga M Tello
Maria Roqué
Silvina B Nadin
Diego M Marzese, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, USAFollow
Laura M Vargas-Roig

Document Type

Article

Publication Date

1-1-2018

Keywords

Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; CpG Islands; DNA Methylation; Disease-Free Survival; Female; Humans; Immunohistochemistry; Prognosis; Protein Isoforms; Tumor Protein p73

Abstract

AIM: Accumulated evidence suggests that aberrant methylation of the

METHODS:

RESULTS: We observed that the methylation of diverse CpG islands of

CONCLUSIONS: Our findings suggest that high expression of ΔNp73 could be used to determine the aggressiveness of IDCs and could be incorporated in the pathologist's report.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology