TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer

Publication Title

Journal of clinical pathology

Authors

Laura C Gomez
Mayra L Sottile
Martin E Guerrero-Gimenez
Felipe C M Zoppino
Analia L Redondo
Francisco E Gago
Javier I Orozco, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, USAFollow
Olga M Tello
Maria Roqué
Silvina B Nadin
Diego M Marzese, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, USAFollow
Laura M Vargas-Roig

Document Type

Article

Publication Date

1-1-2018

Keywords

Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; CpG Islands; DNA Methylation; Disease-Free Survival; Female; Humans; Immunohistochemistry; Prognosis; Protein Isoforms; Tumor Protein p73

Abstract

AIM: Accumulated evidence suggests that aberrant methylation of the

METHODS:

RESULTS: We observed that the methylation of diverse CpG islands of

CONCLUSIONS: Our findings suggest that high expression of ΔNp73 could be used to determine the aggressiveness of IDCs and could be incorporated in the pathologist's report.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology