Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.

Publication Title

Journal of Alzheimer's disease : JAD

Authors

Somayeh Meysami, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Cancer Institute, Santa Monica, CA, USA.Follow
Cyrus A Raji
Ryan M. Glatt, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA, Providence Saint John's Health Center, Santa Monica, CA, USAFollow
Emily S Popa, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Aarthi Ganapathi, Pacific Neuroscience Institute Pacific Brain Health Center Santa Monica California USA; Providence Saint John's Cancer Institute Department of Translational Neurosciences and Neurotherapeutics Santa Monica California USAFollow
Tess Bookheimer, Pacific Neuroscience Institute Pacific Brain Health Center Santa Monica California USAFollow
Colby B Slyapich, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Kyron P Pierce, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Casey J Richards, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Melanie G Lampa, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
Jaya Mini Gill, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USAFollow
Molly Rapozo, Pacific Neuroscience Institute Pacific Brain Health Center Santa Monica California USAFollow
John F Hodes, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USAFollow
Ynez M Tongson, Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Claudia L Wong, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Mihae Kim, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA., Providence Saint John's Health Center, Santa Monica, CA, USA.Follow
Verna R Porter, Saint John's Cancer Institute and Pacific Neuroscience Institute, Providence and St. Johns Health Center, Santa Monica, CA, USAFollow
Scott Kaiser, Pacific Brain Health Center, Pacific Neuroscience Institute, Los Angeles, CA, United StatesFollow
Stella Panos, Pacific Neuroscience Institute Pacific Brain Health Center Santa Monica California USA; Providence Saint John's Cancer Institute Department of Translational Neurosciences and Neurotherapeutics Santa Monica California USAFollow
Richelin V Dye, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA
Karen J Miller, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA, Providence Saint John's Health Center, Santa Monica, CA, USAFollow
Susan Y Bookheimer, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA
Neil A Martin, Pacific Neuroscience Institute, Providence St John's Health Center, Santa Monica, CA, United StatesFollow
Santosh Kesari, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA, Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USAFollow
Daniel F Kelly, Pacific Neuroscience Institute, Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USAFollow
Jennifer Bramen, Pacific Neuroscience Institute Pacific Brain Health Center Santa Monica California USA; Providence Saint John's Cancer Institute Department of Translational Neurosciences and Neurotherapeutics Santa Monica California USAFollow
Prabha Siddarth, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.Follow
David A Merrill, Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA, Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USAFollow

Document Type

Article

Publication Date

12-14-2022

Keywords

california; sjci; pni; Brain volumes; handgrip; mobility; prevention

Abstract

BACKGROUND: Strength and mobility are essential for activities of daily living. With aging, weaker handgrip strength, mobility, and asymmetry predict poorer cognition. We therefore sought to quantify the relationship between handgrip metrics and volumes quantified on brain magnetic resonance imaging (MRI).

OBJECTIVE: To model the relationships between handgrip strength, mobility, and MRI volumetry.

METHODS: We selected 38 participants with Alzheimer's disease dementia: biomarker evidence of amyloidosis and impaired cognition. Handgrip strength on dominant and non-dominant hands was measured with a hand dynamometer. Handgrip asymmetry was calculated. Two-minute walk test (2MWT) mobility evaluation was combined with handgrip strength to identify non-frail versus frail persons. Brain MRI volumes were quantified with Neuroreader. Multiple regression adjusting for age, sex, education, handedness, body mass index, and head size modeled handgrip strength, asymmetry and 2MWT with brain volumes. We modeled non-frail versus frail status relationships with brain structures by analysis of covariance.

RESULTS: Higher non-dominant handgrip strength was associated with larger volumes in the hippocampus (p = 0.02). Dominant handgrip strength was related to higher frontal lobe volumes (p = 0.02). Higher 2MWT scores were associated with larger hippocampal (p = 0.04), frontal (p = 0.01), temporal (p = 0.03), parietal (p = 0.009), and occipital lobe (p = 0.005) volumes. Frailty was associated with reduced frontal, temporal, and parietal lobe volumes.

CONCLUSION: Greater handgrip strength and mobility were related to larger hippocampal and lobar brain volumes. Interventions focused on improving handgrip strength and mobility may seek to include quantified brain volumes on MR imaging as endpoints.

Area of Special Interest

Neurosciences (Brain & Spine)

Specialty/Research Institute

Neurosciences

Specialty/Research Institute

Geriatrics