Contemporary Pharmacotherapies for Nontuberculosis Mycobacterial Infections: A Narrative Review.

Publication Title

Infect Dis Ther

Authors

Tanner M Johnson
Thomas F Byrd
Wendi K Drummond, Division of Infectious Diseases, Providence Portland Medical Center, Portland, OR, USA.Follow
Lindsey M Childs-Kean
Monica V Mahoney
Jeffrey C Pearson
Christina G Rivera

Document Type

Article

Publication Date

2-1-2023

Keywords

oregon; portland; ppmc

Abstract

Nontuberculous mycobacteria (NTM) are a group of atypical bacteria that may cause a spectrum of clinical manifestations, including pulmonary, musculoskeletal, skin and soft tissue, and cardiac infections. Antimycobacterial medication regimens for NTM infections require multiple agents with prolonged treatment courses and are often associated with poor tolerance in patients and suboptimal clinical outcomes. This review summarizes NTM pharmacotherapy, including treatment concepts, preferred medication regimens according to NTM species and site of infection, and emerging treatment methods for difficult-to-treat species.

Specialty/Research Institute

Infectious Diseases

Specialty/Research Institute

Pharmacy

DOI

10.1007/s40121-022-00750-5