Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report.
Publication Title
Vaccines (Basel)
Authors
Jason D. Goldman, Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA.Follow
Kai Wang, Institute for Systems Biology, Seattle, WA 98103, USA.Follow
Katharina Röltgen
Sandra C A Nielsen
Jared C Roach, Institute for Systems Biology, Seattle, WA, 98109, USA.Follow
Samia N Naccache
Fan Yang
Oliver F Wirz
Kathryn E Yost
Ji-Yeun Lee
Kelly Chun
Terri Wrin
Christos J Petropoulos
Inyoul Lee, Institute for Systems Biology, Seattle, WA 98109, USAFollow
Shannon Fallen, Institute for Systems Biology, Seattle, WA 98103, USA.
Paula M Manner, Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98104, USA.Follow
Julie A Wallick, Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98104, USA.Follow
Heather A Algren, Swedish Medical Center - Swedish Center for Research and InnovationFollow
Kim M Murray, Institute for Systems Biology, Seattle, WA 98103, USA.
Jennifer Hadlock, Institute for Systems Biology, Seattle, WA 98103, USA.Follow
Daniel Chen, Institute for Systems Biology, Seattle, WAFollow
Chengzhen L Dai, Institute for Systems Biology, Seattle, WA 98103, USA.
Dan Yuan, Institute for Systems Biology, Seattle, WA 98103, USA.
Yapeng Su, Institute for Systems Biology, Seattle, WA 98103, USA.
Joshua Jeharajah
William R Berrington, Division of Infectious Diseases, Swedish Medical Center, Seattle, WA, USA, Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USAFollow
George P Pappas, Division of Pulmonology and Critical Care Medicine, Swedish Medical Center, Seattle, WA 98104, USA.Follow
Sonam Nyatsatsang, Divisions of Infectious Disease, Swedish Medical Center, Seattle, WA, USA.Follow
Alexander L Greninger
Ansuman T Satpathy
John S Pauk, Division of Infectious Diseases, Swedish Medical Center, Seattle, WA 98122, USA.Follow
Scott D Boyd
James R Heath, Institute for Systems Biology, Seattle, WA 98109Follow
Publication Date
12-20-2022
Keywords
washington; swedish; renton; seattle; covid-19
Abstract
Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.
Specialty/Research Institute
Infectious Diseases
