Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model.
Publication Title
Entropy (Basel)
Document Type
Article
Publication Date
2-9-2023
Keywords
washington; isb
Abstract
Communication between cells enables the coordination that drives structural and functional complexity in biological systems. Both single and multicellular organisms have evolved diverse communication systems for a range of purposes, including synchronization of behavior, division of labor, and spatial organization. Synthetic systems are also increasingly being engineered to utilize cell-cell communication. While research has elucidated the form and function of cell-cell communication in many biological systems, our knowledge is still limited by the confounding effects of other biological phenomena at play and the bias of the evolutionary background. In this work, our goal is to push forward the context-free understanding of what impact cell-cell communication can have on cellular and population behavior to more fully understand the extent to which cell-cell communication systems can be utilized, modified, and engineered. We use an in silico model of 3D multiscale cellular populations, with dynamic intracellular networks interacting via diffusible signals. We focus on two key communication parameters
Specialty/Research Institute
Institute for Systems Biology
DOI
10.3390/e25020319
