Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.

Publication Title

Clinical cancer research : an official journal of the American Association for Cancer Research

Authors

Bernard A Fox, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, United States.Follow
Walter J Urba, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, United States.Follow
Shawn M Jensen, Earle A. Chiles Research Institute, Portland, OR, United States.Follow
David B Page, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, United States.Follow
Brendan D Curti, Providence Cancer Institute and Earle A. Chiles Research Institute, Portland, OR, United States.Follow
Rachel E Sanborn, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, Oregon, United States.Follow
Rom S Leidner, Providence Cancer Institute, Portland, OR, United States.Follow

Document Type

Article

Publication Date

4-11-2023

Keywords

oregon; chiles

Abstract

The authors of a recent study identified non-canonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens.

Area of Special Interest

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Earle A. Chiles Research Institute

DOI

10.1158/1078-0432.CCR-23-0422