Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.
Clinical cancer research : an official journal of the American Association for Cancer Research
The authors of a recent study identified non-canonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens.
Earle A. Chiles Research Institute
Fox, Bernard A; Urba, Walter J; Jensen, Shawn M; Page, David B; Curti, Brendan D; Sanborn, Rachel E; and Leidner, Rom S, "Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies." (2023). Articles, Abstracts, and Reports. 7231.