Exploring the role of cerebrospinal fluid as analyte in neurologic disorders.

Publication Title

Future Sci OA

Authors

Sandeep C Pingle
Feng Lin
Misa S Anekoji
C Pawan K Patro
Souvik Datta
Lawrence D Jones
Santosh Kesari, Department of Translational Neurosciences, Saint John's Cancer Institute at Providence Saint John's Health Center & Pacific Neuroscience Institute, Santa Monica, CA 90404, USA.Follow
Shashaanka Ashili

Document Type

Article

Publication Date

4-1-2023

Keywords

california; pni; sjci; santa monica

Abstract

The cerebrospinal fluid (CSF) is a clear ultrafiltrate of blood that envelopes and protects the central nervous system while regulating neuronal function through the maintenance of interstitial fluid homeostasis in the brain. Due to its anatomic location and physiological functions, the CSF can provide a reliable source of biomarkers for the diagnosis and treatment monitoring of different neurological diseases, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and primary and secondary brain malignancies. The incorporation of CSF biomarkers into the drug discovery and development can improve the efficiency of drug development and increase the chances of success. This review aims to consolidate the current use of CSF biomarkers in clinical practice and explore future perspectives for the field.

Clinical Institute

Neurosciences (Brain & Spine)

Specialty/Research Institute

Neurosciences

DOI

10.2144/fsoa-2023-0006