Mixed anhydrides at the intersection between peptide and RNA autocatalytic sets: evolution of biological coding.
Publication Title
Interface Focus
Document Type
Article
Publication Date
6-6-2023
Keywords
washington; seattle; isb
Abstract
We present a scenario for the origin of biological coding, a semiotic relationship between chemical information stored in one location that links to chemical information stored in a separate location. Coding originated from cooperation between two, originally separate, collectively autocatalytic sets (CASs), one for nucleic acids and one for peptides. Upon interaction, a series of RNA folding-directed processes led to their joint cooperativity. The aminoacyl adenylate was the first covalent association made by these two CASs and solidified their interdependence, and is a palimpsest of this era, a relic of the original semiotic relationship between RNA and proteins. Coding was driven by selection pressure to eliminate waste in CASs. Eventually a 1
Specialty/Research Institute
Institute for Systems Biology
DOI
10.1098/rsfs.2023.0009
