Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model.

Authors

Ana Margarida Pinto
Mariana Luís
Rinie Geenen
Filipe Palavra
Mark A Lumley
Jacob N Ablin
Kirstine Amris
Jaime Branco
Dan Buskila
João Castelhano
Miguel Castelo-Branco
Leslie J Crofford
Mary-Ann Fitzcharles
Winfried Häuser
Eva Kosek
Philip J Mease, Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, USA; University of Washington School of Medicine, Seattle, WA, USA.Follow
Tiago Reis Marques
Johannes W G Jacobs
Paula Castilho
José A P da Silva

Document Type

Article

Publication Date

8-1-2023

Publication Title

Neuroscience and biobehavioral reviews

Keywords

washington; swedish

Abstract

Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.

Clinical Institute

Neurosciences (Brain & Spine)

Clinical Institute

Mental Health

Department

Neurosciences

Department

Behavioral Health

Department

Rheumatology

Recommended Citation

Pinto, Ana Margarida; Luís, Mariana; Geenen, Rinie; Palavra, Filipe; Lumley, Mark A; Ablin, Jacob N; Amris, Kirstine; Branco, Jaime; Buskila, Dan; Castelhano, João; Castelo-Branco, Miguel; Crofford, Leslie J; Fitzcharles, Mary-Ann; Häuser, Winfried; Kosek, Eva; Mease, Philip J; Marques, Tiago Reis; Jacobs, Johannes W G; Castilho, Paula; and da Silva, José A P, "Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model." (2023). Articles, Abstracts, and Reports. 7424.
https://digitalcommons.providence.org/publications/7424