Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex.
Document Type
Article
Publication Date
5-30-2023
Publication Title
Elife
Keywords
washington; swedish; swedish neuro; cerebral cortex; human; neuroscience; synaptic connection; Humans; Neocortex; Synaptic Transmission; In Situ Hybridization, Fluorescence; Prospective Studies; Neurons; Pyramidal Cells; Synapses; Interneurons
Abstract
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where there are major technical challenges in reliably obtaining healthy tissue, conducting multiple patch-clamp recordings on inhibitory cell types, and identifying those cell types. Here, we take advantage of newly developed methods for human neurosurgical tissue analysis with multiple patch-clamp recordings,
Clinical Institute
Neurosciences (Brain & Spine)
Department
Neurosciences
Recommended Citation
Kim, Mean-Hwan; Radaelli, Cristina; Thomsen, Elliot R; Monet, Deja; Chartrand, Thomas; Jorstad, Nikolas L; Mahoney, Joseph T; Taormina, Michael J; Long, Brian; Baker, Katherine; Bakken, Trygve E; Campagnola, Luke; Casper, Tamara; Clark, Michael; Dee, Nick; D'Orazi, Florence; Gamlin, Clare; Kalmbach, Brian E; Kebede, Sara; Lee, Brian R; Ng, Lindsay; Trinh, Jessica; Cobbs, Charles; Gwinn, Ryder P; Keene, C Dirk; Ko, Andrew L; Ojemann, Jeffrey G; Silbergeld, Daniel L; Sorensen, Staci A; Berg, Jim; Smith, Kimberly A; Nicovich, Philip R; Jarsky, Tim; Zeng, Hongkui; Ting, Jonathan T; Levi, Boaz P; and Lein, Ed, "Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex." (2023). Articles, Abstracts, and Reports. 7500.
https://digitalcommons.providence.org/publications/7500
