Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex.
Publication Title
Elife
Document Type
Article
Publication Date
5-30-2023
Keywords
washington; swedish; swedish neuro; cerebral cortex; human; neuroscience; synaptic connection; Humans; Neocortex; Synaptic Transmission; In Situ Hybridization, Fluorescence; Prospective Studies; Neurons; Pyramidal Cells; Synapses; Interneurons
Abstract
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where there are major technical challenges in reliably obtaining healthy tissue, conducting multiple patch-clamp recordings on inhibitory cell types, and identifying those cell types. Here, we take advantage of newly developed methods for human neurosurgical tissue analysis with multiple patch-clamp recordings,
Clinical Institute
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
DOI
10.7554/eLife.81863
