Title

Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex.

Document Type

Article

Publication Date

5-30-2023

Publication Title

Elife

Keywords

washington; swedish; swedish neuro; cerebral cortex; human; neuroscience; synaptic connection; Humans; Neocortex; Synaptic Transmission; In Situ Hybridization, Fluorescence; Prospective Studies; Neurons; Pyramidal Cells; Synapses; Interneurons

Abstract

Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where there are major technical challenges in reliably obtaining healthy tissue, conducting multiple patch-clamp recordings on inhibitory cell types, and identifying those cell types. Here, we take advantage of newly developed methods for human neurosurgical tissue analysis with multiple patch-clamp recordings,

Clinical Institute

Neurosciences (Brain & Spine)

Department

Neurosciences

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