Cytoplasmic Sensing in Innate Immunity

Document Type

Book

Publication Date

11-25-2022

Publication Title

Encyclopedia of Cell Biology (Second Edition)

Keywords

washington; isb; ALR; Host-pathogen crosstalk; Inflammasomes; Innate immunity; NLR; Systems biology; TLR

Abstract

The innate immune system detects ligands of microbial or endogenous origin by employing a network of pattern recognition receptors (PRRs) present on the cell surface or in the cytosol, and mounts an inflammatory response for host defense or wound healing. Here we discuss the major classes of innate sensors that survey the intracellular environment, the mechanistic aspects of their activation and regulation including assembly of multi-protein signaling complexes, spatial relocation to specific subcellular structures, signal integration from multiple PRR pathways, and how this orchestrated set of events is integrated into an immune response.

Department

Institute for Systems Biology

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