Cytoplasmic Sensing in Innate Immunity
Publication Title
Encyclopedia of Cell Biology (Second Edition)
Document Type
Book
Publication Date
11-25-2022
Keywords
washington; isb; ALR; Host-pathogen crosstalk; Inflammasomes; Innate immunity; NLR; Systems biology; TLR
Abstract
The innate immune system detects ligands of microbial or endogenous origin by employing a network of pattern recognition receptors (PRRs) present on the cell surface or in the cytosol, and mounts an inflammatory response for host defense or wound healing. Here we discuss the major classes of innate sensors that survey the intracellular environment, the mechanistic aspects of their activation and regulation including assembly of multi-protein signaling complexes, spatial relocation to specific subcellular structures, signal integration from multiple PRR pathways, and how this orchestrated set of events is integrated into an immune response.
Specialty/Research Institute
Institute for Systems Biology
