The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development.
Document Type
Article
Publication Date
10-3-2023
Publication Title
medRxiv
Keywords
washington; isb; genomics
Abstract
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain regions: the anterior cingulate cortex and dorsolateral prefrontal cortex. Across both regions, we observed notable differences in neuronal chromatin accessibility between schizophrenia cases and controls. A per-sample disease pseudotime was positively associated with genetic liability for schizophrenia. Organizing chromatin into
Clinical Institute
Mental Health
Clinical Institute
Neurosciences (Brain & Spine)
Clinical Institute
Women & Children
Department
Behavioral Health
Department
Neurosciences
Department
Perinatology/Neonatology
Recommended Citation
Girdhar, Kiran; Bendl, Jaroslav; Baumgartner, Andrew; Therrien, Karen; Venkatesh, Sanan; Mathur, Deepika; Dong, Pengfei; Rahman, Samir; Kleopoulos, Steven P; Misir, Ruth; Reach, Sarah M; Auluck, Pavan K; Marenco, Stefano; Lewis, David A; Haroutunian, Vahram; Funk, Cory C; Voloudakis, Georgios; Hoffman, Gabriel E; Fullard, John F; and Roussos, Panos, "The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development." (2023). Articles, Abstracts, and Reports. 8076.
https://digitalcommons.providence.org/publications/8076
