Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction.
Publication Title
Circ Heart Fail
Document Type
Article
Publication Date
11-1-2023
Keywords
Humans; Female; Middle Aged; Male; Ventricular Dysfunction, Right; Heart Failure; Retrospective Studies; Pulmonary Artery; Obesity; Stroke; Ventricular Function, Right; heart failure; obesity; pulmonary hypertension; oregon; cards; cards publication
Abstract
BACKGROUND: Right ventricular (RV) dysfunction is associated with increased mortality across a spectrum of cardiovascular diseases. The role of obesity in RV dysfunction and adverse outcomes is unclear.
METHODS: We examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. Linear regression was used to examine the association of obesity with hemodynamic indices of RV dysfunction (pulmonary artery pulsatility index, right atrial pressure:pulmonary capillary wedge pressure ratio, RV stroke work index). Cox models were used to examine the association of RV function measures with clinical outcomes.
RESULTS: Among 8285 patients (mean age, 63 years; 40% women), higher body mass index was associated with worse indices of RV dysfunction, including lower pulmonary artery pulsatility index (ß, -0.23; SE, 0.01;
CONCLUSIONS: Patients with obesity had worse hemodynamic measured indices of RV function across a broad hospital-based sample. While RV dysfunction was associated with worse clinical outcomes including mortality and heart failure hospitalization, this association was especially pronounced among individuals with higher body mass index.
Clinical Institute
Cardiovascular (Heart)
Clinical Institute
Digestive Health
Specialty/Research Institute
Cardiology
Specialty/Research Institute
Pulmonary Medicine
DOI
10.1161/CIRCHEARTFAILURE.123.010524 http
