Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction.

Document Type

Article

Publication Date

11-1-2023

Publication Title

Circ Heart Fail

Keywords

Humans; Female; Middle Aged; Male; Ventricular Dysfunction, Right; Heart Failure; Retrospective Studies; Pulmonary Artery; Obesity; Stroke; Ventricular Function, Right; heart failure; obesity; pulmonary hypertension; oregon; cards; cards publication

Abstract

BACKGROUND: Right ventricular (RV) dysfunction is associated with increased mortality across a spectrum of cardiovascular diseases. The role of obesity in RV dysfunction and adverse outcomes is unclear.

METHODS: We examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. Linear regression was used to examine the association of obesity with hemodynamic indices of RV dysfunction (pulmonary artery pulsatility index, right atrial pressure:pulmonary capillary wedge pressure ratio, RV stroke work index). Cox models were used to examine the association of RV function measures with clinical outcomes.

RESULTS: Among 8285 patients (mean age, 63 years; 40% women), higher body mass index was associated with worse indices of RV dysfunction, including lower pulmonary artery pulsatility index (β, -0.23; SE, 0.01;

CONCLUSIONS: Patients with obesity had worse hemodynamic measured indices of RV function across a broad hospital-based sample. While RV dysfunction was associated with worse clinical outcomes including mortality and heart failure hospitalization, this association was especially pronounced among individuals with higher body mass index.

Clinical Institute

Cardiovascular (Heart)

Clinical Institute

Digestive Health

Department

Cardiology

Department

Pulmonary Medicine

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