The Dance Between Tumor Molecular Biology and Antitumor Immune Response.
Publication Title
Clinical cancer research : an official journal of the American Association for Cancer Research
Document Type
Article
Publication Date
1-17-2024
Keywords
california; sjci; Mice; Humans; Animals; CD8-Positive T-Lymphocytes; T-Lymphocytes, Regulatory; Brain Neoplasms; Antigens, Neoplasm; Antigen Presentation; Tumor Microenvironment; Cell Line, Tumor
Abstract
When the cyclin kinase 4/6 inhibitor abemaciclib was sequenced with PD-1 blockade in mostly immunologically "cold" murine models, enhanced immune-mediated antitumor effects-including increased lifespan, recruitment of CD8 cells to tumor, reduction of regulatory T-cell and immunosuppressive cytokines in tumor, increased tumor antigen presentation, and broadening of the T-cell receptor repertoire-were achieved in both cutaneous and brain metastases. See related article by Nayyar et al., p. 420.
Area of Special Interest
Cancer
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Oncology
Specialty/Research Institute
Neurosciences
DOI
10.1158/1078-0432.CCR-23-2642
