The Dance Between Tumor Molecular Biology and Antitumor Immune Response.
Document Type
Article
Publication Date
1-17-2024
Publication Title
Clinical cancer research : an official journal of the American Association for Cancer Research
Keywords
california; sjci; Mice; Humans; Animals; CD8-Positive T-Lymphocytes; T-Lymphocytes, Regulatory; Brain Neoplasms; Antigens, Neoplasm; Antigen Presentation; Tumor Microenvironment; Cell Line, Tumor
Abstract
When the cyclin kinase 4/6 inhibitor abemaciclib was sequenced with PD-1 blockade in mostly immunologically "cold" murine models, enhanced immune-mediated antitumor effects-including increased lifespan, recruitment of CD8 cells to tumor, reduction of regulatory T-cell and immunosuppressive cytokines in tumor, increased tumor antigen presentation, and broadening of the T-cell receptor repertoire-were achieved in both cutaneous and brain metastases. See related article by Nayyar et al., p. 420.
Clinical Institute
Cancer
Clinical Institute
Neurosciences (Brain & Spine)
Department
Oncology
Department
Neurosciences
Recommended Citation
Margolin, K A, "The Dance Between Tumor Molecular Biology and Antitumor Immune Response." (2024). Articles, Abstracts, and Reports. 8117.
https://digitalcommons.providence.org/publications/8117
