Parkinson's Disease Diagnosis Using miRNA Biomarkers and Deep Learning.
Publication Title
Front Biosci (Landmark Ed)
Document Type
Article
Publication Date
1-12-2024
Keywords
Humans; Parkinson Disease; MicroRNAs; Deep Learning; Machine Learning; Biomarkers; california; pni
Abstract
BACKGROUND: The current standard for Parkinson's disease (PD) diagnosis is often imprecise and expensive. However, the dysregulation patterns of microRNA (miRNA) hold potential as a reliable and effective non-invasive diagnosis of PD.
METHODS: We use data mining to elucidate new miRNA biomarkers and then develop a machine-learning (ML) model to diagnose PD based on these biomarkers.
RESULTS: The best-performing ML model, trained on filtered miRNA dysregulated in PD, was able to identify miRNA biomarkers with 95.65% accuracy. Through analysis of miRNA implicated in PD, thousands of descriptors reliant on gene targets were created that can be used to identify novel biomarkers and strengthen PD diagnosis.
CONCLUSIONS: The developed ML model based on miRNAs and their genomic pathway descriptors achieved high accuracies for the prediction of PD.
Area of Special Interest
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
DOI
10.31083/j.fbl2901004
