The intersection of frailty and metabolism.
Publication Title
Cell Metab
Document Type
Article
Publication Date
5-7-2024
Keywords
washington; isb
Abstract
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how metabolic diseases may modify the degree of frailty in old age and suggest that frailty may predispose toward metabolic disease. Metabolic interventions that can mitigate the degree of frailty in people are reviewed. New treatment strategies developed in animal models that are poised for translation to humans are also considered. We suggest that maintaining a youthful metabolism into older age may be protective against frailty.
Specialty/Research Institute
Pathology & Laboratory Medicine
Specialty/Research Institute
Pharmacy
Specialty/Research Institute
Institute for Systems Biology
DOI
10.1016/j.cmet.2024.03.012
