Toxin-Induced Liver Injury and Extracorporeal Treatment of Liver Failure.
Publication Title
Adv Kidney Dis Health
Document Type
Article
Publication Date
3-1-2024
Keywords
washington; everett; prmc; Humans; Chemical and Drug Induced Liver Injury; Extracorporeal Membrane Oxygenation; Liver Failure; Renal Dialysis; Plasma Exchange; Liver Failure, Acute; Xenobiotics
Abstract
Poisoning with a large variety of drugs and naturally occurring toxins may result in acute liver injury and failure. Drug-induced liver injury is a major cause of liver failure nationwide, and it is likely that nephrologists will be involved in treating patients with these conditions. A number of xenobiotics resulting in liver toxicity may cause acute kidney injury or other organ injury as well. Most agents causing drug- or toxin-induced liver failure lack specific therapies, although a few xenobiotics such as acetaminophen have effective antidotal therapies if administered prior to development of hepatotoxicity. The nephrologist should be aware that extracorporeal treatment of liver failure associated with drugs and toxins may be indicated, including therapies conventionally performed by nephrologists (hemodialysis, continuous kidney replacement therapy), therapies occasionally performed by nephrologists and other specialists (plasma exchange, albumin dialysis, hemadsorption), and therapies performed by other specialists (extracorporeal membrane oxygenation). An overview of the role of these therapies in liver failure is provided, as well as a review of their limitations and potential complications.
Area of Special Interest
Digestive Health
Specialty/Research Institute
Hepatology
Specialty/Research Institute
Nephrology
Specialty/Research Institute
Pharmacy
DOI
10.1053/j.akdh.2024.03.001
