BASDAI versus ASDAS in evaluating axial involvement in patients with psoriatic arthritis: a pooled analysis of two phase 3 studies.

Publication Title

Rheumatol Adv Pract

Document Type

Article

Publication Date

1-1-2024

Keywords

washington; swedish

Abstract

OBJECTIVE: In the absence of axial psoriatic arthritis (axPsA)-specific tools, the BASDAI and Ankylosing Spondylitis Disease Activity Score (ASDAS) are used to assess axial symptoms in patients with PsA. Here, we assessed the performance of BASDAI and ASDAS in patients with PsA.

METHODS: Patients with active PsA in DISCOVER-1 and DISCOVER-2 (ClinicalTrials.gov: NCT03162796 and NCT03158285, respectively) with or without axPsA but with available baseline BASDAI information were analysed; those with investigator-identified axial symptoms and imaging-confirmed sacroiliitis comprised the axPsA cohort. Correlations between BASDAI/ASDAS and clinical variables were assessed with Pearson's coefficient (

RESULTS: At baseline in the axPsA (

CONCLUSION: BASDAI and ASDAS performed similarly in patients with active PsA and axial involvement, independent of peripheral disease involvement, supporting their performance in assessing axial disease activity.

TRIAL REGISTRATION: ClinicalTrials.gov, http://clinicaltrials.gov, NCT03162796 and NCT03158285.

Clinical Institute

Orthopedics & Sports Medicine

Specialty

Orthopedics

Specialty

Rheumatology

Specialty

Diagnostic Imaging

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