Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements.

Publication Title

Cellular and molecular life sciences : CMLS

Document Type

Article

Publication Date

6-20-2024

Keywords

california; sjci; genomics; Humans; Neoplasms; Mutation; Regulatory Sequences, Nucleic Acid; Genome, Human; Transcription Factors; Gene Expression Regulation, Neoplastic

Abstract

Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", but rather comprise critical elements involved in gene expression. These gene regulatory elements (GREs) include enhancers, insulators, silencers, and gene promoters. Notably, new evidence shows how mutations within these regions substantially influence gene expression programs, especially in the context of cancer. Advances in high-throughput sequencing technologies have accelerated the identification of somatic and germline single nucleotide mutations in non-coding genomic regions. This review provides an overview of somatic and germline non-coding single nucleotide alterations affecting transcription factor binding sites in GREs, specifically involved in cancer biology. It also summarizes the technologies available for exploring GREs and the challenges associated with studying and characterizing non-coding single nucleotide mutations. Understanding the role of GRE alterations in cancer is essential for improving diagnostic and prognostic capabilities in the precision medicine era, leading to enhanced patient-centered clinical outcomes.

Clinical Institute

Cancer

Specialty

Oncology

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